1. Anti-aging

Studies has shown that L-Ergothioneine is regulated through multiple pathways to achieve anti-aging:

Mitigates Telomere Shortening: As the telomere shortening rate is a powerful predictor of animals’ life expectancy, L-Ergothioneine helps to preserve telomere length. One study indicates that ergothioneine-treated telomere has a smaller shortening rate than the control group, especially under oxidative conditions resulting in longer telomere length. Reducing telomere shortening rate by 25% in 4 weeks of EGT supplementation.

Increasing SIRT6 expression: SIRT6 is a longevity protein that can inhibit aging by promoting DNA damage repair, maintaining normal chromosome structure, modulating energy metabolism, and regulating senescence cellular events. L-Ergothioneine has been proven that up-regulates SIRT6 expression and protect from senescence.

Reducing oxidative damage: The accumulation of oxidative damage is correlated with disease development as aging. L-Ergothioneine, according to multiple research studies, is a potent antioxidant that fights oxidative stress in three separate mechanisms.

2. Protects DNA and mitochondrial

The OCTN1 receptor, L-Ergothioneine specific transporter, is expressed on the membrane of mitochondria which allows L-Ergothioneine to concentrate in mitochondria and directly protect against DNA damage by scavenging oxidative radicals and absorbing UV radiation to block its effects on DNA.

3. Skin Health

L-Ergothioneine is effective for skin care and can be used as a promising antiphotoaging ingredient. Data shows that L-Ergothioneine dose-dependently increases the pro-collagen expression, thus enhancing collagen production.