Quality standards, including physical, chemical, and microbiological tests and criteria are important parts of the safety and efficacy of ingredients. Bonerge is aiming to offer premium-quality Fisetin ingredients with potent healthy values to the world.

1. BeFisetin stands out for its pure colour and lower impurities

2.  A full set of quality characterization make sure you get the ture and the best Fisetin

With professional analytical scientists and advanced equipments, top quality and consistency among batches are the golden promises to our customers from Bonerge.

The identity test, purity test, impurity test and assay test that usually applied in the pharmaceutical industry and guided by USP requirements, is at the center of Bonerge's quality research.

3. Authoritative and credible Reference Standard(RS) for assay analysis 

A trusted RS is like an impartial judge. While some suppliers use purity to mislead consumers intentionally, their Fisetin touted 98% purity might be less than 85% in assay. Reference substances are of great importance for a test method. However, no such official RS is available from USP or EP. Bonerge sourced Fisetin RS globally and finally chooses a reputable German Reference Standard from Sigma as its external standard.

4.  Top quality botanical source for eco-friendly and cost-efficiently manufacturing

 We are making efforts to manufacture eco-friendly and cost-efficiently to make BeFisetin more affordable to consumers. Historically fisetin has been extracted from the trunks of Rhus plant tree . However, the tree grows slowly and takes several years, even hundreds of years, before the trees are harvested and used. Thus, each tree can only be used once.

Bonerge carefully determined the content of fisetin in other parts of the Rhus succedanea. Branches and leaves are gradually being used instead of trunks. Now Bonerge uses only leaves to produce fisetin on a large scale.

Senolytics, the substance that can effectively remove senescent cells are considered one promising way to achieve healthy aging from the current science. 

1. Oveall Anti-aging, Extend Lifespan

A panel of flavonoid polyphenols was screened for senolytic activity. Fisetin is the most potent senolytic of the 11 tested compounds including Resveratrol and Quercetin. The excellent senolytic activity enable Fisetin to be a potent active ingredient that effectively extended lifespan. In one study, mice given fisetin lived an average of 10% extension of lifespan-even when treatment was started at the human equivalent of 75 years old.

2. Brain Anti-aging, Improve Cognitive and Mood Health

The accumulation of senescent cells in the brain can cause structural and functional changes that result in cognitive impairment. In the study, Fisetin supplementation effectively reduced the senescent cells in different areas in the brain like in several brain regions like cortex, hippocampus, and cerebellum. It is helpful for cognitive health and mood health.

3. Musculoskeletal Anti-aging, Strengthen Aged Bones  

In elderly individuals, fractures due to osteoporosis and functional deficit represent a significant healthcare burden. Novel treatment strategies for age-related bone loss are desperately needed. Supplementation of fisetin for weeks could significantly attenuate bone density loss. Mice treated with fisetin. had significantly higher scores for Hounsfield unit intensity, bone mineral density compared to the untreated group.

4. Skin Anti-aging, Promote Skin Rejuvenation

Senescent cells accumulate with age in the skin, leading to a decline in various aspect of skin function. Fisetin can selectively remove senescent cells in the skin thus combating skin aging and senescent cell induces damage in the skin.

5. Internal Organs Anti-aging, Reducing The Risk of Pulmonary and Kidney Fibrosis

Idiopathic pulmonary fibrosis is associated with aging, and is increasing in both incidence and prevalence with the rapid rise in aging populations worldwide. Fisetin protects lung microstructure and alleviates bleomycin-induced pulmonary fibrosis by rescuing alveolar epithelial cells in the lung from senescence.

Also, a research discovered that fisetin supplementation eliminates senescent TECs in kidney through its action as a senolytic and limits the proliferation of fibroblasts of TGF-β both in vivo and in vitro. Suggested that fisetin can attenuate kidney fibrosis, decrease SASP expression, and increase TEC proliferation.